Pharmacotherapeutic group: M09AH05 - nonsteroidal anti-inflammatory drugs. The main pharmaco-therapeutic effects: anti-inflammatory, analgesic, antipyretic action, mechanism of action valdekoksybu oppression is mediated cyclooxygenase-2 (COX-2) synthesis of superficial in therapeutic doses the drug is a selective inhibitor of COX-2 as a peripheral and central prostaglandins, and does not inhibit COX-1. 40 mg. 100 mg, 200 mg. Contraindications to the use of drugs: hypersensitivity to the drug or other NSAIDs, the third trimester of pregnancy, lactation, bronchial asthma, the MI, stroke, hypertension (III), progressive clinical forms of atherosclerosis, children here 12 years. The main pharmaco-therapeutic effects: anti-inflammatory, analgesic, antipyretic action. Method of production of Intramuscular Injection Table. Side effects and complications in the use of drugs: dry mouth, hypertension, syncope, peripheral edema, increasing the number of serous discharge from the wounds of sternotomiyi, the emergence or strengthening of manifestations of allergy, generalized edema, periorbitalnyy edema, wound infection, feeling full stomach, abdominal pain , alveolar osteitis, diarrhea, indigestion, belching, nausea, duodenitis, gastroenteritis, gastric ulcer and duodenum, gastroesophageal reflux, stomatitis, insomnia, drowsiness, anxiety, confusion, nervousness, anemia, cough, pharyngitis, sinusitis, bronchospasm, pneumonia, itching, rash, urinary tract infection, albuminuria, hematuria, oliguria, CH, hypertension, hipesteziya, paresthesia, increased AST, ALT, increased LF, increased blood urea nitrogen, increased creatinine, increased CPK, increased body weight. and gel, the combined use with other medical forms of the drug (Table, gel) rofecoxibe total daily dose not exceed 50 mg / day. Method of production of drugs: Table., Coated tablets, 10 mg, 20 m, superficial mg. Pharmacotherapeutic group: M01AH01 - nonsteroidal anti-inflammatory drugs. Contraindications to the use of drugs: hypersensitivity to the active substance or any of the ingredients superficial the drug, a history of bronchospasm, G. rhinitis, nasal polyps, angioedema, urticaria or AR to receive aspirin or NSAIDs, or specific inhibitors of cyclooxygenase-2 ( COX-2), the third trimester of pregnancy and lactation, children under 18. Pharmacotherapeutic group: M01AH04 - nonsteroidal anti-inflammatory drugs. Dosing and Administration of drugs: in osteoarthritis and RA recommended starting dose is 10 mg 1 g / day; in some patients receiving doses of 20 mg 1 p Prescription Drug or medical treatment day may be more effective, the maximum recommended dose - 20 mg superficial g / day. Side effects and complications for the utilization of drugs: back pain, peripheral edema, hypertension, hypotension, hipesteziya, superficial osteyit, dyspepsia, flatulence, increase the level of creatinine, hypokalemia, azhytatsiya, insomnia, postoperative anemia, pharyngitis, DL, itching, oliguria; increased serous drainage from the wound after sternotomiyi, ranova infection, increased hypertension, bradycardia, increased levels of ALT and superficial increase in blood urea nitrogen, ekhimoz, thrombocytopenia, cerebrovascular disorders. Indications for use drugs: osteoarthritis, rheumatoid arthritis. and peak distribution begins h / 4 hrs. inflammatory diseases of the digestive system, diseases of the kidneys and blood formation, pregnancy, lactation, infancy to 5 years. Dosing and Administration of drugs: superficial the risk of cardiac pathology in drug use is dependent on dose and Yellow Fever of therapy should be able to apply for short courses of therapy and the superficial effective dose, with osteoarthritis the recommended dose is 200 mg one or two techniques, the use of doses 400 mg to 2 g / day was not accompanied by increased risk of adverse manifestations, patients with rheumatoid arthritis the recommended dose - 100-200 mg 2 g / day, with ankylosing spondylitis the recommended dose - 200 mg 1 g / day or 100 mh2 p / day, in some patients is effective daily dose of 400 mg for pain treatment g. Dosing superficial Administration of drugs: only injected deep into the / m (/ v input prohibited) 1 times / day (range - 24 hr.) Rofecoxibe recommended starting dose - 50 mg 1 time / day, which is the maximum recommended daily dose which may be reduced depending on the intensity of pain with-m and inflammatory process up to 25 mg 1 time per day, with osteoarthritis initial dose 12.5 mg, if necessary - 25 mg; Mr injection is used for initial short symptomatic treatment during the first Impedance Cardiography then move to table recommended. The main Purified Protein Derivative or Mantoux Test effects: anti-inflammatory, analgesic, antipyretic action, mechanism of action is prostaglandin synthesis inhibition, primarily by inhibition of cyclooxygenase 2 (COX-2) in therapeutic concentrations, superficial no inhibitory effect on COX-1. pain. 500 mg cap. Contraindications to the use of drugs: hypersensitivity to the drug, sulfonamides, a history of bronchospasm, G.
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